Breaking from the group, Alice became aware of her martial arts skills when she instinctively kicked a Cerberus. Forced to climb through ventilation, they aimed to reach the train before their escape could be sealed off. The group had lost several commandos in a trap set by the security system, so was incapable in fighting off the escaped Undead, resulting in the infection of almost the entire team. When the mission successfully deactivated the Red Queen, it was revealed that the entire staff had been infected with the T-virus and, consequently, the security system was no longer able to prevent the Undead researchers from escaping. On their way they found Spence, who had also been rendered amnesiac due to the nerve gas. Accepting her amnesia but not having enough commandos to stay upstairs, Alice and Addison - their prisoner - were taken into The Hive as they investigated the reason for the security system killing the research staff. Umbrella's " Sanitation" commando team arrived right after its leader James Shade demanded information from Alice. Briefly exploring the mansion in a failed attempt to look for clues to her identity, she was met by Addison, who had come for Anna and the virus sample. Knocked out by the Red Queen's release of gas, Alice woke up naked in the bathroom in an amnesiac condition, having no recollection of who or where she was. However, Spence caused the mansion's defense systems to activate by releasing the T-virus into the Hive. She awoke later, finding Spence gone she picked out some clothes to wear and went for a shower. When Alice returned, Spence initiated sex with her. Considering the takedown of Umbrella in this manner to be a worthless accomplishment, he instead made his own plan to steal a sample of the virus with his own security clearance, sell it on the black market and run away with Alice with the market money. Unbeknownst to them, Spence discovered this plan. Alice had likely been influenced by Alicia's innate sense of compassion. Rather than arrest her, Alice offered to help Lisa expose Umbrella's bio-weapons research through a plan to disable the Red Queen security system and allow the theft of a T-virus sample. In 2002, Alice began talking to an Umbrella researcher named Lisa Addison, who was secretly a mole working for former FBI agent Matt Addison. They became romantically involved at some point down the line. To the public, she was married to Spence however, their marriage was a sham for the sake of guarding the mansion. Alice's purpose was to protect the Looking Glass House and she remained unaware of her true nature as a clone, thinking that she was the original as all Umbrella clones were created to believe.
Alice ultimately crippled Umbrella's leadership nonetheless, paving the way for its Red Queen computer system to take full control of its remaining assets, now intent on humanity's destruction. As she had not succumbed to the T-virus and transformed into an Undead, the acquisition of Alice became a major goal to the company as a means of surviving the pandemic. Enhanced by a T-virus infection cured and re-infected, Alice became the test subject of an Umbrella research project designated "Project Alice" granted with superhuman abilities, she was able to survive the viral outbreak in Raccoon City and several years of the T-virus' spread across the Earth. Infected after escaping the Undead-infested facility, Alice was taken away by Umbrella for testing. Both Alice and Spence were knocked unconscious when the security system released noxious gas and were rendered amnesiac. This plan ultimately failed when her co-worker, Spence stole the virus samples with the intention of getting rich on the black market and leaked the virus into the lab to kill the research staff in the confusion. Originally a high-ranking Umbrella security operator, she joined a deep cover operation by members of the US law enforcement to reveal the company's illegal viral research data to the world. Isaacs after regaining her memoriesĪlice was a leading party in the conflict against the Umbrella Corporation during the Global T-virus Pandemic.